In a new series of experiments will involve patients suffering from pleomorphic glioblastoma and anaplastic astrocytoma, the two most dangerous forms of cancer that are localized predominantly in the brain, its membrane of the vessels. An experimental drug called PAC-1, a feature of which is that he is able to easily pass through the blood-brain barrier (a structure similar to a filter, selectively transmissive to the brain of various substances). The effect of PAC-1, which will be tested in conjunction with temosolomida (the drug of choice in chemotherapy of brain cancer). The tests on the enzyme procaspase-3. It is present in cancer cells and is inactive, but activation of this enzyme leads to cell death. She's just starting to break down from the inside. Cancer cells have learned to suppress the activity of this enzyme, but PAC-1 "turns on" the gene and causes the tumor to "kill herself". And the drug that matter, does not affect healthy cells.
As mentioned earlier, a substance successfully tested in culture of human cells, and on pet dogs with naturally occurring osteosarcoma, lymphoma, and glioma. The trials revealed that the combination of PAC-1 with chemotherapeutic drugs provides the opportunity to significantly reduce the size of tumors and even get rid of them. In addition, all previous studies revealed virtually no complications (including Central nervous system), except for a small gastrointestinal disorders.
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